| The original NC 50 was today's US 1. Today's NC 50 was originally NC 21 and, for a brief time, NC 13, which was redesignated US 15A in 1936.
For a few years, no road was designated NC 50 in Wake County, but in 1937 current NC 50 from US 70 south into Johnston County was formed. This was the extent of 50 in Wake County for nearly 20 years; in 1956 15A was largely replaced by US 401, but north of Raleigh an extended NC 50 took its place.
Old Creedmoor Road in northern Wake County was certainly US 15A, and may have carried NC 50 for a year or two after 15A was replaced. Today's NC 50 has largely remained the same since then, with the exception of a ten-year stretch from 1985 to 1995 where 50 was routed along the Beltline instead of through downtown.
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